Abstract: Oil and gas exploration in the Yinggehai-Qiongdongnan (Ying-Qiong) Basin witnesses the transition from mid-shallow to mid-deep zones, from simple to complex structures, and from high temperature and high pressure to ultra-high temperature and high pressure. To address key challenges in these exploration fields, systematic research and field application have been conducted, giving rise to the development of innovative techniques including OBN data acquisition and processing for seismic shadow zones, data processing and reservoir prediction in rugged seabed areas, and pressure prediction under geologically high-temperature high-pressure conditions. This paper gives an overview of application scenarios and outcomes of key techniques as well as exploration breakthroughs. In view of seismic challenges in the deep Ying-Qiong Basin, such as poor seismic data quality, unclear petrophysical relationships, and routine techniques unfeasible for reservoir prediction and hydrocarbon detection, further efforts should focus on technical development for seismic acquisition, data processing, and geophysical exploration to provide solid support for exploration breakthroughs in the Ying-Qiong Basin.